Bayesian Analysis of Mutational Spectra

Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity

Cancer is widely recognized as a genetic disease in which somatic mutations are sequentially accumulated to drive tumor progression. Although genomic landscape studies are informative for individual cancer types, a comprehensive comparative study of tumorigenic mutations across cancer types based on integrative data sources is still a pressing need. We systematically analyzed ~10(6) non-synonym...

The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma Running Title: Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma

Affiliations 1. Michigan Center for Translational Pathology, University of Michigan Medical School 2. Department of Pathology, University of Michigan Medical School 3. Department of Dermatology, University of Michigan Medical School 4. Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, India 5. Department of Urology, Henry Ford Health System, Detroit, MI 6. Howard Hugh...

The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.

Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine tumor. Merkel cell polyomavirus (MCPyV) may contribute to tumorigenesis in a subset of tumors via inhibition of tumor suppressors such as retinoblastoma (RB1) by mutated viral T antigens, but the molecular pathogenesis of MCPyV-negative MCC is largely unexplored. Through our MI-ONCOSEQ precision oncology study,...

Mutational spectra and immunohistochemical analyses of p53 in human cancers.

Isogeometric analysis: vibration analysis, Fourier and wavelet spectra

This paper presents the Fourier and wavelet characterization of vibratio...